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In multivariate logistic regression analysis, only duration of TPN at or before first positive blood culture remained independently associated with LOGNS (p53 years old. Mechanical ventilation, total parenteral nutrition (TPN) and its duration, presence of a central venous line and its duration, use of specific antibiotics and the occurrence of necrotising enterocolitis at or before the first positive culture were all significantly associated with case status in univariate analysis. There was no significant difference between cases and controls regarding maternal risk factors. Overall case death was 27% in cases versus 13.5% in controls (p=0.08). The majority of infants were of very low birthweight (VLBW 79%), and cases and controls were well matched (median gestation 26 weeks). (28%), Escherichia coli (27%) and Klebsiella spp. 73 cases of LOGNS were identified of which 48 were inborn and included in the study (incidence 1.85/1000 live births). Controls were healthy infants matched for gestation and time of admission to the neonatal unit. (2) Their mother education level in the birth-defect group (25.6%) were significantly lower than that in control group (30.0%, P48 h of life) invasive gram-negative infections diagnosed between 19. The top six defect diseases were congenital heart disease (112 cases), total harelip (cleft lip cleft lip with palate: 85 cases), polydactyly (53 cases), neural tube defects (38 cases), congenital hydrocephalus (37 cases) and limb reduction defect (27 cases) in turn, which amounts to 353 cases (54.48%, 353/648). The congenital malformational rate accounts for about 6.034‰. (1) There are 466 congenital malformational fetuses in the total of 77 231 fetuses collected in 75 hospitals. The study and control group's parents were interviewed by an uniformed questionnaire which was designed specially with influence factors of birth defects. Case-control and the three-level of monitor network of birth defects were used in the study in the participating 75 hospitals (Qingdao Women and Children's Medical Center, Affiliated Hospital of Medical College Qingdao University, Qingdao Municipal Hospital, etc.). The health born fetuses were set as control in the same period. The congenital malformational fetuses born from 13 week of gestation to 7 days after birth were selected as the study group between April 1st, 2009 and March 31st, 2010. To investigate the influence factors of birth defects. Xiu, Xin-hong Yuan, Li Wang, Xiao-ming Chen, Yu-hua Wan, Ai-hua Fu, Ping
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